Glutathione
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Research summary
Glutathione is a naturally occurring tripeptide (γ-glutamylcysteinylglycine) produced in nearly every human cell, and the body's primary intracellular antioxidant, studied for its role in neutralizing reactive oxygen species and supporting detoxification pathways in the liver.
In a randomized trial in elderly adults with type 2 diabetes, six months of oral glutathione supplementation reduced markers of oxidative damage and improved HbA1c versus placebo. A separate pilot study found glutathione therapy reduced oxidative stress markers in non-alcoholic fatty liver disease. Reduced glutathione levels have also been studied as a marker in psychiatric and neurodegenerative conditions, though causal treatment effects in those areas remain under investigation.
Sources: PMC9137531, 2022 (diabetes RCT); PMC5578552 (NAFLD pilot study); PMC10366746 (psychiatric review). Findings from published research —not a claim about this product, and not evidence of safety or effectiveness for human use.
Decoding the Benefits
- Improved blood sugar control (HbA1c) alongside reduced oxidative damage markers over a 6-month trial in older adults.
- Shown to ease oxidative stress in a liver-disease pilot study as well.
