Fat Blaster

Ingredients

• L-Carnitine300 mg
• Methionine25 mg
• Inositol50 mg
• Choline50 mg
• Vitamin B121 mg
• Vitamin B650 mg
• NADH50 mg

Research summary

Fat Blaster combines seven compounds historically used in "lipotropic" or "MIC" (methionine/inositol/choline) formulations: L-Carnitine, Methionine, Inositol, Choline, Vitamin B12, Vitamin B6, and NADH. L-Carnitine has the largest human evidence base of the seven — a 2020 dose-response meta-analysis pooling 43 randomized trials found supplementation associated with an average 1.1 kg reduction in body weight and 1.2 kg reduction in fat mass, with no significant change in body fat percentage, and benefit concentrated in overweight or obese participants who also changed diet or exercise. Methionine, Inositol, and Choline make up the classic "MIC" combination; the rationale is mechanistic rather than trial-proven — methionine supplies methyl groups for the liver's phosphatidylcholine synthesis pathway, which choline is itself a substrate of, and both are proposed to support how the liver packages and exports fat as VLDL.

Controlled human data on the MIC combination itself is sparse. In one of the few controlled studies to test two of these compounds directly, researchers gave choline and L-carnitine separately to lean and obese cats over six-week periods and found neither altered body composition or energy expenditure compared to control. The one identified human randomized trial of Myo-Inositol alone — in 48 adults with obesity and fatty liver disease given 4 g/day for eight weeks — measured lipid profile and liver markers rather than body weight. Vitamin B6 and B12 are established cofactors in metabolic and nervous-system pathways, but published literature doesn't show that supplementing beyond adequate levels accelerates fat metabolism in people who aren't deficient. NADH's human research is limited to small, preliminary studies in neurological conditions, including one short injectable trial that found no significant effect. No published study has evaluated these seven compounds combined in a single preparation.

Sources: Pharmacological Research, 2020 (L-carnitine dose-response meta-analysis); Frontiers in Nutrition, 2023 (myo-inositol NAFLD RCT); PMC10410278 (choline/L-carnitine, feline model); consumer health literature on NADH (PeaceHealth/University of Michigan Health). Findings from published research —not a claim about this product, and not evidence of safety or effectiveness for human use.