AOD-9604

Research summary

AOD-9604 is a synthetic peptide fragment corresponding to a specific region of the human growth hormone molecule associated with GH's fat-metabolizing activity, developed in an attempt to isolate that effect from GH's growth-promoting effects.

In genetically obese mice, AOD-9604 reduced body weight and increased fat oxidation without raising plasma IGF-1, consistent with a mechanism distinct from GH's growth effects. In human randomized controlled trials (roughly 300 participants), treated groups lost modestly more weight than placebo, though researchers have noted this early signal did not hold up as robustly in larger follow-on study designs —real-world efficacy remains an open question in the literature.

Sources: Metabolic studies of the lipolytic domain of human growth hormone (obese-mouse and knockout models). Findings from published research —not a claim about this product, and not evidence of safety or effectiveness for human use.